Reaction Details |
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Target | Tyrosine-protein kinase Fer |
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Ligand | BDBM50520589 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1881334 (CHEMBL4382833) |
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IC50 | 2.0±n/a nM |
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Citation | Jang, J; Son, JB; To, C; Bahcall, M; Kim, SY; Kang, SY; Mushajiang, M; Lee, Y; Jänne, PA; Choi, HG; Gray, NS Discovery of a potent dual ALK and EGFR T790M inhibitor. Eur J Med Chem136:497-510 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Fer |
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Name: | Tyrosine-protein kinase Fer |
Synonyms: | FER | FER_HUMAN | TYK3 |
Type: | Enzyme |
Mol. Mass.: | 94643.38 |
Organism: | Homo sapiens (Human) |
Description: | P16591 |
Residue: | 822 |
Sequence: | MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQ
MNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQ
IEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHM
LHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEI
VNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNL
TAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQAL
EELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSK
FESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDF
LVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITK
KSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQE
LKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQ
LVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLK
QIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMS
APQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
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BDBM50520589 |
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n/a |
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Name | BDBM50520589 |
Synonyms: | CHEMBL4473365 |
Type | Small organic molecule |
Emp. Form. | C28H36ClN7O4S |
Mol. Mass. | 602.148 |
SMILES | COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 |
Structure |
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