| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 4 |
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| Ligand | BDBM50521158 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1883059 (CHEMBL4384558) |
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| IC50 | 251±n/a nM |
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| Citation |  Adlere, I; Sun, S; Zarca, A; Roumen, L; Gozelle, M; Viciano, CP; Caspar, B; Arimont, M; Bebelman, JP; Briddon, SJ; Hoffmann, C; Hill, SJ; Smit, MJ; Vischer, HF; Wijtmans, M; de Graaf, C; de Esch, IJP; Leurs, R Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists. Eur J Med Chem162:631-649 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 4 |
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| Name: | C-X-C chemokine receptor type 4 |
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| Synonyms: | C-X-C chemokine receptor type 4 | C-X-C chemokine receptor type 4 (CXCR4) | CD_antigen=CD184 | CXC-R4 | CXCR-4 | CXCR4 | CXCR4_HUMAN | FB22 | Fusin | HM89 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 39754.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P61073 |
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| Residue: | 352 |
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| Sequence: | MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
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| BDBM50521158 |
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| n/a |
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| Name | BDBM50521158 |
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| Synonyms: | CHEMBL4463564 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26Cl2N2 |
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| Mol. Mass. | 377.351 |
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| SMILES | Cc1cccc(CNCC2CCN(Cc3c(Cl)cccc3Cl)CC2)c1 |
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| Structure | 
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