| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease 1 |
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| Ligand | BDBM50228717 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_212705 |
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| IC50 | 27400±n/a nM |
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| Citation |  Plummer, JS; Berryman, KA; Cai, C; Cody, WL; DiMaio, J; Doherty, AM; Eaton, S; Edmunds, JJ; Holland, DR; Lafleur, D; Levesque, S; Narasimhan, LS; Rubin, JR; Rapundalo, ST; Siddiqui, MA; Susser, A; St-Denis, Y; Winocour, P Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1' modifications. Bioorg Med Chem Lett9:835-40 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease 1 |
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| Name: | Serine protease 1 |
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| Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 26557.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07477 |
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| Residue: | 247 |
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| Sequence: | MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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| BDBM50228717 |
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| n/a |
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| Name | BDBM50228717 |
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| Synonyms: | (6S,8aS)-4-Oxo-2-(3-phenyl-propionyl)-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid [(S)-4-guanidino-1-(1-methyl-1H-imidazole-2-carbonyl)-butyl]-amide | (6S,8aS)-N-((S)-5-guanidino-1-(1-methyl-1H-imidazol-2-yl)-1-oxopentan-2-yl)-4-oxo-2-(3-phenylpropanoyl)-octahydropyrrolo[1,2-a]pyrazine-6-carboxamide | CHEMBL256030 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H36N8O4 |
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| Mol. Mass. | 536.6259 |
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| SMILES | [#6]-n1ccnc1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6@H]-2-[#6]-[#7](-[#6]-[#6](=O)-[#7]-1-2)-[#6](=O)-[#6]-[#6]-c1ccccc1 |
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| Structure | 
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