| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil collagenase |
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| Ligand | BDBM50523951 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1891528 (CHEMBL4393355) |
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| IC50 | 282±n/a nM |
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| Citation |  Kalinin, DV; Agoglitta, O; Van de Vyver, H; Melesina, J; Wagner, S; Riemann, B; Schäfers, M; Sippl, W; Löffler, B; Holl, R Proline-based hydroxamates targeting the zinc-dependent deacetylase LpxC: Synthesis, antibacterial properties, and docking studies. Bioorg Med Chem27:1997-2018 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil collagenase |
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| Name: | Neutrophil collagenase |
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| Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
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| Type: | Enzyme |
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| Mol. Mass.: | 53413.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22894 |
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| Residue: | 467 |
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| Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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| BDBM50523951 |
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| n/a |
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| Name | BDBM50523951 |
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| Synonyms: | CHEMBL4437091 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N2O4 |
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| Mol. Mass. | 420.5008 |
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| SMILES | CCCCCc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NO |r| |
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| Structure | 
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