| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-arginine methyltransferase CARM1 |
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| Ligand | BDBM50194756 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1896028 (CHEMBL4398063) |
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| IC50 | 32±n/a nM |
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| Citation |  Guo, Z; Zhang, Z; Yang, H; Cao, D; Xu, X; Zheng, X; Chen, D; Wang, Q; Li, Y; Li, J; Du, Z; Wang, X; Chen, L; Ding, J; Shen, J; Geng, M; Huang, X; Xiong, B Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia. J Med Chem62:5414-5433 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-arginine methyltransferase CARM1 |
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| Name: | Histone-arginine methyltransferase CARM1 |
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| Synonyms: | CARM1 | CARM1_HUMAN | Coactivator-associated arginine methyltransferase 1 | Coactivator-associated arginine methyltransferase 1 (CARM1) | PRMT4 | Protein arginine N-methyltransferase 4 | Protein arginine methyltransferase 4 (PRMT4) |
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| Type: | Protein |
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| Mol. Mass.: | 65855.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86X55 |
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| Residue: | 608 |
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| Sequence: | MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEV
RAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSF
YNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPG
KVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDE
QLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFL
EAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRC
LFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTT
PSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSSVGHNNLIPLAN
TGIVNHTHSRMGSIMSTGIVQGSSGAQGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIP
TNTMHYGS
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| BDBM50194756 |
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| n/a |
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| Name | BDBM50194756 |
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| Synonyms: | CHEMBL3961701 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H24N2O |
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| Mol. Mass. | 248.3639 |
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| SMILES | CNCCN1CCC(CC1)OCc1ccccc1 |
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| Structure | 
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