Reaction Details |
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Target | Non-receptor tyrosine-protein kinase TYK2 |
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Ligand | BDBM50526619 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1900330 (CHEMBL4402445) |
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Ki | 26±n/a nM |
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Citation | Liu, C; Lin, J; Moslin, R; Tokarski, JS; Muckelbauer, J; Chang, C; Tredup, J; Xie, D; Park, H; Li, P; Wu, DR; Strnad, J; Zupa-Fernandez, A; Cheng, L; Chaudhry, C; Chen, J; Chen, C; Sun, H; Elzinga, P; D'arienzo, C; Gillooly, K; Taylor, TL; McIntyre, KW; Salter-Cid, L; Lombardo, LJ; Carter, PH; Aranibar, N; Burke, JR; Weinstein, DS Identification of Imidazo[1,2- ACS Med Chem Lett10:383-388 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Non-receptor tyrosine-protein kinase TYK2 |
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Name: | Non-receptor tyrosine-protein kinase TYK2 |
Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2 |
Type: | Protein |
Mol. Mass.: | 133666.03 |
Organism: | Homo sapiens (Human) |
Description: | P29597 |
Residue: | 1187 |
Sequence: | MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
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BDBM50526619 |
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n/a |
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Name | BDBM50526619 |
Synonyms: | CHEMBL4439957 |
Type | Small organic molecule |
Emp. Form. | C21H18F2N8O2 |
Mol. Mass. | 452.4168 |
SMILES | CNc1cc(Nc2cccn(-c3ccc(F)cn3)c2=O)nn2c(cnc12)C(=O)N[C@@H]1C[C@@H]1F |r| |
Structure |
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