Reaction Details |
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Target | Purine nucleoside phosphorylase |
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Ligand | BDBM50081807 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_162186 |
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IC50 | 330±n/a nM |
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Citation | Yokomatsu, T; Hayakawa, Y; Suemune, K; Kihara, T; Soeda, S; Shimeno, H; Shibuya, S Synthesis and biological evaluation of 1,1-difluoro-2-(tetrahydro-3-furanyl)ethylphosphonic acids possessing a N9-purinylmethyl functional group at the ring. a new class of inhibitors for purine nucleoside phosphorylases. Bioorg Med Chem Lett9:2833-6 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Purine nucleoside phosphorylase |
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Name: | Purine nucleoside phosphorylase |
Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
Type: | Enzyme |
Mol. Mass.: | 32119.53 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 289 |
Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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BDBM50081807 |
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n/a |
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Name | BDBM50081807 |
Synonyms: | ({(1R,2S)-2-[2-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-ethyl]-cyclopropyl}-difluoro-methyl)-phosphonic acid | CHEMBL97006 |
Type | Small organic molecule |
Emp. Form. | C11H14F2N5O4P |
Mol. Mass. | 349.2305 |
SMILES | Nc1nc2n(CC[C@@H]3C[C@H]3C(F)(F)P(O)(O)=O)cnc2c(=O)[nH]1 |
Structure |
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