Reaction Details |
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Target | Purine nucleoside phosphorylase |
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Ligand | BDBM50214705 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_162011 (CHEMBL764862) |
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IC50 | 540±n/a nM |
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Citation | Yokomatsu, T; Hayakawa, Y; Suemune, K; Kihara, T; Soeda, S; Shimeno, H; Shibuya, S Synthesis and biological evaluation of 1,1-difluoro-2-(tetrahydro-3-furanyl)ethylphosphonic acids possessing a N9-purinylmethyl functional group at the ring. a new class of inhibitors for purine nucleoside phosphorylases. Bioorg Med Chem Lett9:2833-6 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Purine nucleoside phosphorylase |
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Name: | Purine nucleoside phosphorylase |
Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
Type: | Enzyme |
Mol. Mass.: | 32119.53 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 289 |
Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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BDBM50214705 |
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n/a |
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Name | BDBM50214705 |
Synonyms: | 5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-difluoropentylphosphonate | 9-(5',5'-difluoro-5'-phosphonopentyl)guanine | 9-(5,5-DIFLUORO-5-PHOSPHONOPENTYL)GUANINE | CHEMBL236708 | [5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-1,1-difluoro-pentyl]-phosphonic acid |
Type | Small organic molecule |
Emp. Form. | C10H14F2N5O4P |
Mol. Mass. | 337.2198 |
SMILES | Nc1nc2n(CCCCC(F)(F)P(O)(O)=O)cnc2c(=O)[nH]1 |
Structure |
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