Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50081909 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_55095 (CHEMBL665356) |
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Ki | 65±n/a nM |
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Citation | Chowdhury, SF; Villamor, VB; Guerrero, RH; Leal, I; Brun, R; Croft, SL; Goodman, JM; Maes, L; Ruiz-Perez, LM; Pacanowska, DG; Gilbert, IH Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase. J Med Chem42:4300-12 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50081909 |
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n/a |
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Name | BDBM50081909 |
Synonyms: | 5-(3-(benzyloxy)benzyl)pyrimidine-2,4-diamine | 5-(3-Benzyloxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL274031 |
Type | Small organic molecule |
Emp. Form. | C18H18N4O |
Mol. Mass. | 306.3617 |
SMILES | Nc1ncc(Cc2cccc(OCc3ccccc3)c2)c(N)n1 |
Structure |
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