| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
|---|
| Ligand | BDBM50527935 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1904112 (CHEMBL4406334) |
|---|
| IC50 | 36000±n/a nM |
|---|
| Citation |  Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Discovery and Structure-Activity Relationship Study of ( J Med Chem63:4880-4895 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
|---|
| Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
|---|
| Synonyms: | PI42B_HUMAN | PIP4K2B | PIP5K2B | Phosphatidylinositol-5-phosphate 4-kinase type-2 beta |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47382.97 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_774395 |
|---|
| Residue: | 416 |
|---|
| Sequence: | MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNV
PVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNS
VTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLL
PQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKD
NDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEE
RAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKK
EVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
|
|
|
|---|
| BDBM50527935 |
|---|
| n/a |
|---|
| Name | BDBM50527935 |
|---|
| Synonyms: | CHEMBL4567681 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H19N3O3S |
|---|
| Mol. Mass. | 381.448 |
|---|
| SMILES | CC(=O)Nc1cccc(c1)-c1cncc(c1)-c1ccc(NS(C)(=O)=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
