| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-C |
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| Ligand | BDBM50529875 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1910729 (CHEMBL4413175) |
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| IC50 | 23±n/a nM |
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| Citation |  Xi, M; Chen, T; Wu, C; Gao, X; Wu, Y; Luo, X; Du, K; Yu, L; Cai, T; Shen, R; Sun, H CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors. Eur J Med Chem164:77-91 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-C |
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| Name: | Cyclin-C |
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| Synonyms: | CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33244.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107900 |
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| Residue: | 283 |
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| Sequence: | MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQ
VIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRF
SYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIV
NDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQ
WKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
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| BDBM50529875 |
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| n/a |
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| Name | BDBM50529875 |
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| Synonyms: | CHEMBL4580000 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19FN4O2 |
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| Mol. Mass. | 414.4317 |
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| SMILES | Fc1ccc(cc1)-c1ccncc1\C=C\C(=O)Nc1ccc(CCc2nnco2)cc1 |
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| Structure | 
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