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TargetCyclin-dependent kinase 19
LigandBDBM50459995
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1910726 (CHEMBL4413172)
IC50 10±n/a nM
Citation Xi, MChen, TWu, CGao, XWu, YLuo, XDu, KYu, LCai, TShen, RSun, H CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors. Eur J Med Chem164:77-91 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 19
Name:Cyclin-dependent kinase 19
Synonyms:CDC2-related protein kinase 6 | CDC2L6 | CDK11 | CDK19 | CDK19_HUMAN | Cell division cycle 2-like protein kinase 6 | Cell division protein kinase 19 | Cyclin-dependent kinase 11 | Death-preventing kinase | KIAA1028
Type:Serine/Threonine protein kinase
Mol. Mass.:56816.68
Organism:Homo sapiens (Human)
Description:Q9BWU1
Residue:502
Sequence:
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGIS
MSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKP
MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH
KVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLN
EDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTG
AGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQST
LGYSSSSQQSSQYHPSHQAHRY
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  Blast E-value cutoff:
BDBM50459995
n/a
NameBDBM50459995
Synonyms:CHEMBL4225966 | US11471446, Compound DBA-10
TypeSmall organic molecule
Emp. Form.C15H18Br2N4
Mol. Mass.414.138
SMILESCc1c(Br)c(Br)c2CCCn3c(nc1c23)N1CCNCC1
Structure
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