Reaction Details |
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Target | Neuronal acetylcholine receptor subunit alpha-7 |
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Ligand | BDBM50530219 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1911481 (CHEMBL4413927) |
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Ki | 1.4±n/a nM |
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Citation | Manetti, D; Garifulina, A; Bartolucci, G; Bazzicalupi, C; Bellucci, C; Chiaramonte, N; Dei, S; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Spirova, E; Shelukhina, I; Teodori, E; Varani, K; Tsetlin, V; Romanelli, MN New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of ?7 and ?3* Nicotinic Receptors. J Med Chem62:1887-1901 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neuronal acetylcholine receptor subunit alpha-7 |
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Name: | Neuronal acetylcholine receptor subunit alpha-7 |
Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) |
Type: | Enzyme |
Mol. Mass.: | 56502.44 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q05941 |
Residue: | 502 |
Sequence: | MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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BDBM50530219 |
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n/a |
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Name | BDBM50530219 |
Synonyms: | CHEMBL4454983 |
Type | Small organic molecule |
Emp. Form. | C37H50N2O10 |
Mol. Mass. | 682.8003 |
SMILES | [H][C@]12C[C@]3([H])[C@]([H])([C@H]1OC)[C@](O)(C[C@@H]2OC)[C@@]1(O)[C@@H](OC)[C@@]2([H])[C@@]33[C@H](CC[C@@]2(COC(=O)c2ccccc2N2C(=O)C[C@H](C)C2=O)CN(CC)[C@]13[H])OC |r,TLB:2:3:50:21.18,27:21:50:10.5.3,28:27:23:16.18,10:16:46.47.27:23,THB:8:7:3.2:10.13.12,52:24:50.46.47:21,19:18:50:10.5.3,19:18:46.47.27:23,47:50:21.18:10.5.3,11:10:50:21.18,26:27:23:16.18,24:23:46.47.27:16.18,48:47:23:16.18| |
Structure |
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