| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-dependent protein kinase |
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| Ligand | BDBM50530639 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1913587 (CHEMBL4416170) |
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| IC50 | 1.7±n/a nM |
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| Citation |  Matralis, AN; Malik, A; Penzo, M; Moreno, I; Almela, MJ; Camino, I; Crespo, B; Saadeddin, A; Ghidelli-Disse, S; Rueda, L; Calderon, F; Osborne, SA; Drewes, G; Böesche, M; Fernández-Álvaro, E; Martin Hernando, JI; Baker, DA Development of Chemical Entities Endowed with Potent Fast-Killing Properties against J Med Chem62:9217-9235 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-dependent protein kinase |
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| Name: | cGMP-dependent protein kinase |
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| Synonyms: | n/a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 97679.99 |
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| Organism: | Plasmodium falciparum |
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| Description: | ChEMBL_862297 |
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| Residue: | 853 |
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| Sequence: | MEEDDNLKKGNERNKKKAIFSNDDFTGEDSLMEDHLELREKLSEDIDMIKTSLKNNLVCS
TLNDNEILTLSNYMQFFVFKSGNLVIKQGEKGSYFFIINSGKFDVYVNDKKVKTMGKGSS
FGEAALIHNTQRSATIIAETDGTLWGVQRSTFRATLKQLSNRNFNENRTFIDSVSVFDML
TEAQKNMITNACVIQNFKSGETIVKQGDYGDVLYILKEGKATVYINDEEIRVLEKGSYFG
ERALLYDEPRSATIIAKEPTACASICRKLLNIVLGNLQVVLFRNIMTEALQQSEIFKQFS
GDQLNDLADTAIVRDYPANYNILHKDKVKSVKYIIVLEGKVELFLDDTSIGILSRGMSFG
DQYVLNQKQPFKHTIKSLEVCKIALITETCLADCLGNNNIDASIDYNNKKSIIKKMYIFR
YLTDKQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEIVKNKKRLRTLGKNDY
FGERALLYDEPRTASVISKVNNVECWFVDKSVFLQIIQGPMLAHLEERIKMQDTKVEMDE
LETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPF
IIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERNI
VYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILGKGYGCTVDIW
ALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINLMKRLLCRLPQG
RIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSETYAEDIDIKQIEEEDAEDDE
EPLNDEDNWDIDF
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| BDBM50530639 |
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| n/a |
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| Name | BDBM50530639 |
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| Synonyms: | CHEMBL4461276 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26F2N6S |
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| Mol. Mass. | 504.597 |
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| SMILES | Cc1nc(Nc2nccc(n2)-c2sc(nc2-c2ccc(F)cc2)C2CCNCC2)cc(C2CC2)c1F |
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| Structure | 
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