| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2C8 |
|---|
| Ligand | BDBM50533234 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1924661 (CHEMBL4427617) |
|---|
| IC50 | 100±n/a nM |
|---|
| Citation |  Wang, H; Lawson, JD; Scorah, N; Kamran, R; Hixon, MS; Atienza, J; Dougan, DR; Sabat, M Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibitors. Bioorg Med Chem Lett26:4334-9 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2C8 |
|---|
| Name: | Cytochrome P450 2C8 |
|---|
| Synonyms: | CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55839.23 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10632 |
|---|
| Residue: | 490 |
|---|
| Sequence: | MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
|
|
|
|---|
| BDBM50533234 |
|---|
| n/a |
|---|
| Name | BDBM50533234 |
|---|
| Synonyms: | CHEMBL4437930 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H11ClF2N4 |
|---|
| Mol. Mass. | 356.757 |
|---|
| SMILES | Fc1cc(F)c(cc1Cl)-c1cc(Nc2ccncc2)c2cc[nH]c2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
