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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | TGF-beta receptor type-1 | ||
| Ligand | BDBM50533224 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1924658 (CHEMBL4427614) | ||
| IC50 | 6.3±n/a nM | ||
| Citation |  Wang, H; Lawson, JD; Scorah, N; Kamran, R; Hixon, MS; Atienza, J; Dougan, DR; Sabat, M Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibitors. Bioorg Med Chem Lett26:4334-9 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| TGF-beta receptor type-1 | |||
| Name: | TGF-beta receptor type-1 | ||
| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I | ||
| Type: | enzyme | ||
| Mol. Mass.: | 55968.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36897 | ||
| Residue: | 503 | ||
| Sequence: |
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| BDBM50533224 | |||
| n/a | |||
| Name | BDBM50533224 | ||
| Synonyms: | CHEMBL4474551 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H13ClFN5O | ||
| Mol. Mass. | 393.802 | ||
| SMILES | Cn1c2cnccc2n(-c2cc(nc3[nH]ccc23)-c2cc(Cl)ccc2F)c1=O |(44.86,-2.72,;43.96,-3.97,;42.43,-3.98,;41.4,-2.83,;39.89,-3.15,;39.42,-4.63,;40.45,-5.76,;41.95,-5.44,;43.2,-6.34,;43.21,-7.88,;41.88,-8.65,;41.88,-10.19,;43.21,-10.96,;44.54,-10.19,;46.02,-10.67,;46.93,-9.42,;46.02,-8.16,;44.54,-8.64,;40.55,-10.96,;39.21,-10.19,;37.88,-10.96,;36.55,-10.18,;37.88,-12.5,;39.22,-13.27,;40.55,-12.5,;41.88,-13.26,;44.44,-5.43,;45.91,-5.91,)| | ||
| Structure | 
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