| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50533384 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1925214 (CHEMBL4428286) |
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| IC50 | 1000±n/a nM |
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| Citation |  Tang, J; Liu, F; Nagy, E; Miller, L; Kirby, KA; Wilson, DJ; Wu, B; Sarafianos, SG; Parniak, MA; Wang, Z 3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations. J Med Chem59:2648-59 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50533384 |
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| n/a |
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| Name | BDBM50533384 |
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| Synonyms: | CHEMBL4545702 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16N2O5 |
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| Mol. Mass. | 340.33 |
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| SMILES | COc1ccc(cc1)-c1ccccc1Oc1cc(=O)n(O)c(=O)n1C |
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| Structure | 
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