| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM50089315 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_40131 (CHEMBL656784) |
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| Ki | 24.1±n/a nM |
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| Citation |  Bedos, P; Amblard, M; Subra, G; Dodey, P; Luccarini, JM; Paquet, JL; Pruneau, D; Aumelas, A; Martinez, J A rational approach to the design and synthesis of a new bradykinin B(1) receptor antagonist. J Med Chem43:2387-94 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40508.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46663 |
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| Residue: | 353 |
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| Sequence: | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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| BDBM50089315 |
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| n/a |
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| Name | BDBM50089315 |
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| Synonyms: | CHEMBL80461 | {3-[2-(2-{8-[2-(2,6-Diamino-hexanoylamino)-5-guanidino-pentanoyl]-4-oxo-1-phenethyl-1,3,8-triaza-spiro[4.5]dec-3-yl}-acetylamino)-3-hydroxy-propionylamino]-4-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazepin-5-yl}-acetic acid(JMV1640) |
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| Type | Small organic molecule |
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| Emp. Form. | C43H62N12O9S |
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| Mol. Mass. | 923.092 |
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| SMILES | NCCCCC(N)C(=O)NC(CCCNC(N)=N)C(=O)N1CCC2(CC1)N(CCc1ccccc1)CN(CC(=O)NC(CO)C(=O)N[C@@H]1CSc3ccccc3N(CC(O)=O)C1=O)C2=O |
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| Structure | 
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