| Reaction Details |
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 | Report a problem with these data |
| Target | Delta-type opioid receptor |
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| Ligand | BDBM50533719 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1926738 (CHEMBL4429810) |
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| IC50 | 39±n/a nM |
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| Citation |  Váradi, A; Marrone, GF; Palmer, TC; Narayan, A; Szabó, MR; Le Rouzic, V; Grinnell, SG; Subrath, JJ; Warner, E; Kalra, S; Hunkele, A; Pagirsky, J; Eans, SO; Medina, JM; Xu, J; Pan, YX; Borics, A; Pasternak, GW; McLaughlin, JP; Majumdar, S Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit ?-Arrestin-2. J Med Chem59:8381-97 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Delta-type opioid receptor |
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| Name: | Delta-type opioid receptor |
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| Synonyms: | DOR-1 | K56 | MSL-2 | OPIATE Delta | OPRD_MOUSE | Opioid receptors; mu and delta | Oprd1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40577.25 |
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| Organism: | MOUSE |
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| Description: | P32300 |
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| Residue: | 372 |
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| Sequence: | MELVPSARAELQSSPLVNLSDAFPSAFPSAGANASGSPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTQPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRTPCGRQEPGSLRRPRQATTRERVTAC
TPSDGPGGGAAA
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| BDBM50533719 |
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| n/a |
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| Name | BDBM50533719 |
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| Synonyms: | CHEMBL4441457 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N2O5 |
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| Mol. Mass. | 450.5268 |
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| SMILES | [H][C@@]12C[C@@H]([C@H](CC)CN1CC[C@]21Nc2cccc(-c3ccoc3)c2C1=O)C(=C/OC)\C(=O)OC |r| |
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| Structure | 
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