| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Taste receptor type 1 member 2/3 |
|---|
| Ligand | BDBM50535463 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1930725 (CHEMBL4433976) |
|---|
| EC50 | 24500000±n/a nM |
|---|
| Citation |  Yamada, K; Nakazawa, M; Matsumoto, K; Tagami, U; Hirokawa, T; Homma, K; Mori, S; Matsumoto, R; Saikawa, W; Kitajima, S Unnatural Tripeptides as Potent Positive Allosteric Modulators of T1R2/T1R3. ACS Med Chem Lett10:800-805 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Taste receptor type 1 member 2/3 |
|---|
| Name: | Taste receptor type 1 member 2/3 |
|---|
| Synonyms: | T1R2/T1R3 | Taste Receptor T1R2/T1R3 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 1994278 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Taste receptor type 1 member 2 |
|---|
| Synonyms: | GPR71 | T1R2 | TAS1R2 | TR2 | TS1R2_HUMAN | Taste receptor type 1 member 2 (T1R2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 95182.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q8TE23 |
|---|
| Residue: | 839 |
|---|
| Sequence: | MGPRAKTISSLFFLLWVLAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCK
EYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDN
LLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPAL
LRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETL
PTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIA
SESWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCN
QECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQL
LEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQD
ISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYECQACPN
NEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAG
GPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFK
MASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSC
NPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFM
SAYSGVLVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMRRD
|
|
|
|---|
| Component 2 |
| Name: | Taste receptor type 1 member 3 |
|---|
| Synonyms: | T1R3 | TAS1R3 | TR3 | TS1R3_HUMAN | Taste receptor type 1 member 3 (T1R3) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 93393.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q7RTX0 |
|---|
| Residue: | 852 |
|---|
| Sequence: | MLGPAVLGLSLWALLHPGTGAPLCLSQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSP
VCTRFSSNGLLWALAMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKA
GSRDIAAYCNYTQYQPRVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETF
PSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHE
GLVPLPRADDSRLGKVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVAS
EAWLTSDLVMGLPGMAQMGTVLGFLQRGAQLHEFPQYVKTHLALATDPAFCSALGEREQG
LEEDVVGQRCPQCDCITLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASGCPAQDP
VKPWQLLENMYNLTFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNGSLRT
ERLKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNPDDIACTF
CGQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQ
ASGGPLACFGLVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQAAEIFV
ESELPLSWADRLSGCLRGPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHMLPTEALV
HCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGCYNRARGLTFAMLAYFITWVSFVP
LLANVQVVLRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLNTPEFFLGGGPGDAQGQ
NDGNTGNQGKHE
|
|
|
|---|
| BDBM50535463 |
|---|
| n/a |
|---|
| Name | BDBM50535463 |
|---|
| Synonyms: | CHEMBL4452237 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H19N3O5 |
|---|
| Mol. Mass. | 333.3392 |
|---|
| SMILES | CC(C)(C)OC(=O)NCc1ccc(o1)-c1cncc(C(O)=O)c1N |
|---|
| Structure | 
|
|---|
Search and Browse
