Reaction Details |
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Target | Taste receptor type 1 member 2/3 |
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Ligand | BDBM50535482 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1930725 (CHEMBL4433976) |
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EC50 | 10500000±n/a nM |
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Citation | Yamada, K; Nakazawa, M; Matsumoto, K; Tagami, U; Hirokawa, T; Homma, K; Mori, S; Matsumoto, R; Saikawa, W; Kitajima, S Unnatural Tripeptides as Potent Positive Allosteric Modulators of T1R2/T1R3. ACS Med Chem Lett10:800-805 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Taste receptor type 1 member 2/3 |
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Name: | Taste receptor type 1 member 2/3 |
Synonyms: | T1R2/T1R3 | Taste Receptor T1R2/T1R3 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1994278 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Taste receptor type 1 member 2 |
Synonyms: | GPR71 | T1R2 | TAS1R2 | TR2 | TS1R2_HUMAN | Taste receptor type 1 member 2 (T1R2) |
Type: | Enzyme |
Mol. Mass.: | 95182.38 |
Organism: | Homo sapiens (Human) |
Description: | Q8TE23 |
Residue: | 839 |
Sequence: | MGPRAKTISSLFFLLWVLAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCK
EYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDN
LLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPAL
LRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETL
PTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIA
SESWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCN
QECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQL
LEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQD
ISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYECQACPN
NEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAG
GPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFK
MASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSC
NPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFM
SAYSGVLVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMRRD
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Component 2 |
Name: | Taste receptor type 1 member 3 |
Synonyms: | T1R3 | TAS1R3 | TR3 | TS1R3_HUMAN | Taste receptor type 1 member 3 (T1R3) |
Type: | Enzyme |
Mol. Mass.: | 93393.60 |
Organism: | Homo sapiens (Human) |
Description: | Q7RTX0 |
Residue: | 852 |
Sequence: | MLGPAVLGLSLWALLHPGTGAPLCLSQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSP
VCTRFSSNGLLWALAMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKA
GSRDIAAYCNYTQYQPRVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETF
PSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHE
GLVPLPRADDSRLGKVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVAS
EAWLTSDLVMGLPGMAQMGTVLGFLQRGAQLHEFPQYVKTHLALATDPAFCSALGEREQG
LEEDVVGQRCPQCDCITLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASGCPAQDP
VKPWQLLENMYNLTFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNGSLRT
ERLKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNPDDIACTF
CGQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQ
ASGGPLACFGLVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQAAEIFV
ESELPLSWADRLSGCLRGPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHMLPTEALV
HCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGCYNRARGLTFAMLAYFITWVSFVP
LLANVQVVLRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLNTPEFFLGGGPGDAQGQ
NDGNTGNQGKHE
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BDBM50535482 |
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n/a |
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Name | BDBM50535482 |
Synonyms: | CHEMBL4522824 |
Type | Small organic molecule |
Emp. Form. | C21H33N5O4 |
Mol. Mass. | 419.5178 |
SMILES | CC(C)[C@@H](CCC(=O)Nc1cncc(C(O)=O)c1N)NC(=O)[C@@H](N)C1CCCCC1 |r| |
Structure |
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