| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
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| Ligand | BDBM50538444 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1972858 (CHEMBL4605676) |
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| EC50 | 162±n/a nM |
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| Citation |  Blomgren, P; Chandrasekhar, J; Di Paolo, JA; Fung, W; Geng, G; Ip, C; Jones, R; Kropf, JE; Lansdon, EB; Lee, S; Lo, JR; Mitchell, SA; Murray, B; Pohlmeyer, C; Schmitt, A; Suekawa-Pirrone, K; Wise, S; Xiong, JM; Xu, J; Yu, H; Zhao, Z; Currie, KS Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases. ACS Med Chem Lett11:506-513 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase SYK |
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| Name: | Tyrosine-protein kinase SYK |
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| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
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| Type: | Enzyme |
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| Mol. Mass.: | 72079.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43405 |
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| Residue: | 635 |
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| Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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| BDBM50538444 |
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| n/a |
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| Name | BDBM50538444 |
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| Synonyms: | CHEMBL4640287 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23N7O |
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| Mol. Mass. | 437.4964 |
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| SMILES | [H][C@]12CC[C@]([H])(CN(C1)c1ccc(Nc3nc(cn4ccnc34)-c3ccc4cn[nH]c4c3)cc1)O2 |r| |
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| Structure | 
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