| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 2 |
|---|
| Ligand | BDBM50538508 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1972979 (CHEMBL4605797) |
|---|
| IC50 | 8.0±n/a nM |
|---|
| Citation |  Mathison, CJN; Chianelli, D; Rucker, PV; Nelson, J; Roland, J; Huang, Z; Yang, Y; Jiang, J; Xie, YF; Epple, R; Bursulaya, B; Lee, C; Gao, MY; Shaffer, J; Briones, S; Sarkisova, Y; Galkin, A; Li, L; Li, N; Li, C; Hua, S; Kasibhatla, S; Kinyamu-Akunda, J; Kikkawa, R; Molteni, V; Tellew, JE Efficacy and Tolerability of Pyrazolo[1,5- ACS Med Chem Lett11:558-565 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fibroblast growth factor receptor 2 |
|---|
| Name: | Fibroblast growth factor receptor 2 |
|---|
| Synonyms: | BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 92015.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P21802 |
|---|
| Residue: | 821 |
|---|
| Sequence: | MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
|
|
|
|---|
| BDBM50538508 |
|---|
| n/a |
|---|
| Name | BDBM50538508 |
|---|
| Synonyms: | CHEMBL4634073 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H32N6O5 |
|---|
| Mol. Mass. | 532.5909 |
|---|
| SMILES | COC(=O)Nc1ccc(cc1)-c1c(OC2CCN(C)CC2)nc2c(cnn2c1N)-c1ccc(OC)c(OC)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
