| Reaction Details |
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 | Report a problem with these data |
| Target | Coiled-coil domain-containing protein 6 |
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| Ligand | BDBM50538517 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1973009 (CHEMBL4605827) |
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| IC50 | 6.2±n/a nM |
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| Citation |  Mathison, CJN; Chianelli, D; Rucker, PV; Nelson, J; Roland, J; Huang, Z; Yang, Y; Jiang, J; Xie, YF; Epple, R; Bursulaya, B; Lee, C; Gao, MY; Shaffer, J; Briones, S; Sarkisova, Y; Galkin, A; Li, L; Li, N; Li, C; Hua, S; Kasibhatla, S; Kinyamu-Akunda, J; Kikkawa, R; Molteni, V; Tellew, JE Efficacy and Tolerability of Pyrazolo[1,5- ACS Med Chem Lett11:558-565 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coiled-coil domain-containing protein 6 |
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| Name: | Coiled-coil domain-containing protein 6 |
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| Synonyms: | CCDC6 | CCDC6_HUMAN | Coiled-coil domain-containing protein 6 | D10S170 | Papillary thyroid carcinoma-encoded protein | Protein H4 | TST1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53294.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109661 |
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| Residue: | 474 |
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| Sequence: | MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIVISPFRLEELT
NRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQARAEQEEEFISNTLFKKI
QALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKK
LENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVS
APPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREE
NLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSP
SSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPSPRRSNSP
DKFKRPTPPPSPNTQTPVQPPPPPPPPPMQPTVPSAATSQPTPSQHSAHPSSQP
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| BDBM50538517 |
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| n/a |
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| Name | BDBM50538517 |
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| Synonyms: | CHEMBL4639022 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H44N8O3S |
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| Mol. Mass. | 644.83 |
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| SMILES | CN1C(C)(C)CC(CC1(C)C)Nc1nc2c(cnn2c(N)c1-c1ccccc1)-c1ccc(cc1)C(=O)N1CCN(CC1)S(C)(=O)=O |
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| Structure | 
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