| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1 |
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| Ligand | BDBM50347389 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1978723 (CHEMBL4611858) |
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| IC50 | 8100±n/a nM |
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| Citation |  Diab, S; Yu, M; Wang, S CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success? J Med Chem63:7458-7474 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cyclin-dependent kinase 1 |
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| Name: | Cyclin-dependent kinase 1 |
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| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34101.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06493 |
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| Residue: | 297 |
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| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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| BDBM50347389 |
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| n/a |
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| Name | BDBM50347389 |
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| Synonyms: | CHEMBL1801932 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H32N6 |
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| Mol. Mass. | 380.5297 |
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| SMILES | CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12 |
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| Structure | 
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