| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 18 |
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| Ligand | BDBM50539721 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1978733 (CHEMBL4611868) |
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| IC50 | >8000±n/a nM |
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| Citation |  Diab, S; Yu, M; Wang, S CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success? J Med Chem63:7458-7474 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cyclin-dependent kinase 18 |
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| Name: | Cyclin-dependent kinase 18 |
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| Synonyms: | 2.7.11.22 | CDK18 | CDK18_HUMAN | Cell division protein kinase 18 | Cyclin-dependent kinase 18 | PCTAIRE-motif protein kinase 3 | PCTAIRE3 | PCTK3 | Serine/threonine-protein kinase PCTAIRE-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54437.90 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117731 |
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| Residue: | 474 |
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| Sequence: | MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST
FSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDL
PKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE
EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMH
NVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNE
VVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTP
TEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAAL
SHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF
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| BDBM50539721 |
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| n/a |
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| Name | BDBM50539721 |
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| Synonyms: | CHEMBL4635959 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H39N7O3 |
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| Mol. Mass. | 497.633 |
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| SMILES | CC(C)c1cnn2c(NC3CCN(CC3)C(=O)O[C@H]3CCN(C3)C(=O)\C=C\CN(C)C)cc(C)nc12 |r| |
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| Structure | 
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