| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-dependent RNA helicase DDX3X |
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| Ligand | BDBM50540792 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1982886 (CHEMBL4616148) |
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| IC50 | 1050±n/a nM |
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| Citation |  Brai, A; Boccuto, A; Monti, M; Marchi, S; Vicenti, I; Saladini, F; Trivisani, CI; Pollutri, A; Trombetta, CM; Montomoli, E; Riva, V; Garbelli, A; Nola, EM; Zazzi, M; Maga, G; Dreassi, E; Botta, M Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor. ACS Med Chem Lett11:956-962 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-dependent RNA helicase DDX3X |
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| Name: | ATP-dependent RNA helicase DDX3X |
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| Synonyms: | DBX | DDX3 | DDX3X | DDX3X_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73247.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_811954 |
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| Residue: | 662 |
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| Sequence: | MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGW
SSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFE
RGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIE
SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILS
QIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVV
YGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQ
IRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVV
WVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDR
EEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGL
ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGAR
DYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWW
GN
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| BDBM50540792 |
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| n/a |
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| Name | BDBM50540792 |
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| Synonyms: | CHEMBL4632918 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24F3N5O2 |
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| Mol. Mass. | 447.4535 |
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| SMILES | COc1cc(ccc1NC(=O)Nc1ccccc1C(F)(F)F)-n1cc(CCC(C)C)nn1 |
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| Structure | 
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