| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src |
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| Ligand | BDBM50097988 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_221672 |
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| IC50 | 35±n/a nM |
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| Citation |  Altmann, E; Missbach, M; Green, J; Susa, M; Wagenknecht, HA; Widler, L 7-Pyrrolidinyl- and 7-piperidinyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett11:853-6 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase Src |
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| Name: | Proto-oncogene tyrosine-protein kinase Src |
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| Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src |
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| Type: | Protein |
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| Mol. Mass.: | 59838.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P12931 |
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| Residue: | 536 |
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| Sequence: | MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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| BDBM50097988 |
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| n/a |
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| Name | BDBM50097988 |
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| Synonyms: | (R)-4-[(R)-4-Amino-5-(4-hydroxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-2-ethoxycarbonylmethyl-pyrrolidine-1-carboxylic acid tert-butyl ester | CHEMBL352666 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31N5O5 |
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| Mol. Mass. | 481.5441 |
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| SMILES | CCOC(=O)C[C@H]1C[C@@H](CN1C(=O)OC(C)(C)C)n1cc(-c2ccc(O)cc2)c2c(N)ncnc12 |
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| Structure | 
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