Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM50543834 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1990293 (CHEMBL4624028) |
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IC50 | 12±n/a nM |
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Citation | Futamura, A; Suzuki, R; Tamura, Y; Kawamoto, H; Ohmichi, M; Hino, N; Tokumaru, Y; Kirinuki, S; Hiyoshi, T; Aoki, T; Kambe, D; Nozawa, D Discovery of ORN0829, a potent dual orexin 1/2 receptor antagonist for the treatment of insomnia. Bioorg Med Chem28:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM50543834 |
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n/a |
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Name | BDBM50543834 |
Synonyms: | CHEMBL4637671 |
Type | Small organic molecule |
Emp. Form. | C22H21FN8O2 |
Mol. Mass. | 448.4529 |
SMILES | Cc1ccc(c(c1)C(=O)N1CCCO[C@H]1Cn1cc(nn1)-c1ccc(F)cn1)-n1nccn1 |r| |
Structure |
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