Reaction Details |
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Target | Growth hormone secretagogue receptor type 1 |
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Ligand | BDBM50544353 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1992276 (CHEMBL4626011) |
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IC50 | 42±n/a nM |
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Citation | Cooper, M; Llinas, A; Hansen, P; Caffrey, M; Ray, A; Sjödin, S; Shamovsky, I; Wada, H; Jellesmark Jensen, T; Sivars, U; Hultin, L; Andersson, U; Lundqvist, S; Gedda, K; Jinton, L; Krutrök, N; Lewis, R; Jansson, P; Gardelli, C Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists. J Med Chem63:9705-9730 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Growth hormone secretagogue receptor type 1 |
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Name: | Growth hormone secretagogue receptor type 1 |
Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) |
Type: | Receptor |
Mol. Mass.: | 41334.57 |
Organism: | Homo sapiens (Human) |
Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. |
Residue: | 366 |
Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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BDBM50544353 |
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n/a |
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Name | BDBM50544353 |
Synonyms: | CHEMBL4649860 |
Type | Small organic molecule |
Emp. Form. | C23H33N5O4S |
Mol. Mass. | 475.604 |
SMILES | CN(C)CCNC(=O)[C@H]1CN(CC[C@@H]1NC(=O)c1cc2cc(C)ccc2[nH]1)S(=O)(=O)C1CC1 |r| |
Structure |
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