| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase type 1D |
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| Ligand | BDBM50545577 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1995991 (CHEMBL4629886) |
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| IC50 | 851±n/a nM |
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| Citation |  Fromont, C; Atzori, A; Kaur, D; Hashmi, L; Greco, G; Cabanillas, A; Nguyen, HV; Jones, DH; Garzón, M; Varela, A; Stevenson, B; Iacobini, GP; Lenoir, M; Rajesh, S; Box, C; Kumar, J; Grant, P; Novitskaya, V; Morgan, J; Sorrell, FJ; Redondo, C; Kramer, A; Harris, CJ; Leighton, B; Vickers, SP; Cheetham, SC; Kenyon, C; Grabowska, AM; Overduin, M; Berditchevski, F; Weston, CJ; Knapp, S; Fischer, PM; Butterworth, S Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity J Med Chem63:6784-6801 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin-dependent protein kinase type 1D |
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| Name: | Calcium/calmodulin-dependent protein kinase type 1D |
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| Synonyms: | CAMK1D | CAMKID | CaM kinase I delta | KCC1D_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42916.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586559 |
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| Residue: | 385 |
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| Sequence: | MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK
GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD
ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST
ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF
DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN
FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSS
SGVSGVGAERRPRPTTVTAVHSGSK
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| BDBM50545577 |
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| n/a |
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| Name | BDBM50545577 |
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| Synonyms: | CHEMBL4642539 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17F3N6O |
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| Mol. Mass. | 354.3303 |
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| SMILES | CN(CCN)c1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1 |
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| Structure | 
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