Reaction Details |
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Target | Dual specificity protein phosphatase 3 |
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Ligand | BDBM50104691 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_214524 (CHEMBL819516) |
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IC50 | 12400±n/a nM |
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Citation | Sodeoka, M; Sampe, R; Kojima, S; Baba, Y; Usui, T; Ueda, K; Osada, H Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition. J Med Chem44:3216-22 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity protein phosphatase 3 |
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Name: | Dual specificity protein phosphatase 3 |
Synonyms: | DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR |
Type: | Hydrolase |
Mol. Mass.: | 20480.58 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 185 |
Sequence: | MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVL
NAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRV
LVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKE
GKLKP
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BDBM50104691 |
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n/a |
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Name | BDBM50104691 |
Synonyms: | CHEMBL423508 | Diazo-[2-(4-hexadecanoyl-3-hydroxy-5-oxo-2,5-dihydro-furan-2-yl)-acetoxy]-acetic acid ethyl ester |
Type | Small organic molecule |
Emp. Form. | C26H40N2O8 |
Mol. Mass. | 508.6044 |
SMILES | CCCCCCCCCCCCCCCC(=O)c1c(O)oc(CC(=O)O[C-]([N+]#N)C(=O)OCC)c1O |
Structure |
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