| Reaction Details |
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 | Report a problem with these data |
| Target | M-phase inducer phosphatase 2 |
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| Ligand | BDBM50106508 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_49028 (CHEMBL662067) |
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| IC50 | 640±n/a nM |
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| Citation |  Lazo, JS; Aslan, DC; Southwick, EC; Cooley, KA; Ducruet, AP; Joo, B; Vogt, A; Wipf, P Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J Med Chem44:4042-9 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| M-phase inducer phosphatase 2 |
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| Name: | M-phase inducer phosphatase 2 |
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| Synonyms: | CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 64985.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 580 |
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| Sequence: | MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMH
DLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMD
PHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEA
GSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPD
RKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKT
LEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQ
QEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETM
VALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKR
VILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQ
DYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
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| BDBM50106508 |
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| n/a |
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| Name | BDBM50106508 |
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| Synonyms: | 7-[2-(3,5-Dibromo-4-hydroxy-phenyl)-ethylamino]-quinoline-5,8-dione | CHEMBL336095 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12Br2N2O3 |
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| Mol. Mass. | 452.097 |
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| SMILES | Oc1cc(N=CCc2cc(Br)c(O)c(Br)c2)c(O)c2ncccc12 |w:5.5| |
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| Structure | 
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