BindingDB PrimarySearch

Found 522 hits with Last Name = 'lazo' and Initial = 'js'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
M-phase inducer phosphatase 2 (Homo sapiens (Human))	BDBM50084504 (CHEMBL3426991) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Competitive inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) after 2...				Bioorg Med Chem 23: 2810-8 (2015) Article DOI: 10.1016/j.bmc.2015.01.043 BindingDB Entry DOI: 10.7270/Q2CJ8G62
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Homo sapiens (Human))	BDBM50096680 ((E)-2-(2-Chloro-phenyl)-ethenesulfonic acid [4-(4-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibitory activity against human recombinant Cdc25B phosphatase enzyme				Bioorg Med Chem Lett 11: 313-7 (2001) BindingDB Entry DOI: 10.7270/Q2DR2TRG
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Homo sapiens (Human))	BDBM50096693 ((E)-2-Naphthalen-2-yl-ethenesulfonic acid (4,5-dip...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibitory activity against human recombinant Cdc25B phosphatase enzyme				Bioorg Med Chem Lett 11: 313-7 (2001) BindingDB Entry DOI: 10.7270/Q2DR2TRG
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50479538 (CAS 381679-98-5 \| CHEMBL490678) Show SMILES CCc1ccc(CCNS(=O)(=O)c2ccc(SC)cc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<5.00E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of CYP3A4				J Med Chem 52: 1247-50 (2009) Article DOI: 10.1021/jm801278g BindingDB Entry DOI: 10.7270/Q23T9M14
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50479539 (CAS 307545-04-6 \| CHEMBL491275) Show SMILES CC(C)c1ccc(OCC(=O)Nc2nc3ccccc3s2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	<5.00E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of CYP3A4				J Med Chem 52: 1247-50 (2009) Article DOI: 10.1021/jm801278g BindingDB Entry DOI: 10.7270/Q23T9M14
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50479540 (CAS 329920-60-7 \| CHEMBL452613) Show SMILES CCc1ccc(OCC(=O)NCc2cccc3ccccc23)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	<5.00E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of CYP3A4				J Med Chem 52: 1247-50 (2009) Article DOI: 10.1021/jm801278g BindingDB Entry DOI: 10.7270/Q23T9M14
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50479541 (CAS 303796-42-1 \| CHEMBL446965) Show SMILES CCc1ccc(OCC(=O)NCCc2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	<5.00E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of CYP3A4				J Med Chem 52: 1247-50 (2009) Article DOI: 10.1021/jm801278g BindingDB Entry DOI: 10.7270/Q23T9M14
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50479542 (CAS 31122-64-2 \| CHEMBL491273) Show SMILES O=C(CCN1C(=O)c2ccccc2C1=O)N1CCCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	<5.00E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of CYP3A4				J Med Chem 52: 1247-50 (2009) Article DOI: 10.1021/jm801278g BindingDB Entry DOI: 10.7270/Q23T9M14
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50479536 (CHEMBL489096) Show SMILES CCc1ccc(OCC(=O)Nc2ccc(C)cc2Br)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	<5.00E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of CYP3A4				J Med Chem 52: 1247-50 (2009) Article DOI: 10.1021/jm801278g BindingDB Entry DOI: 10.7270/Q23T9M14
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50479535 (CAS 160693-53-8 \| CHEMBL491274) Show SMILES CCc1ccc(cc1)N1CC(CC1=O)C(=O)OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	<5.00E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of CYP3A4				J Med Chem 52: 1247-50 (2009) Article DOI: 10.1021/jm801278g BindingDB Entry DOI: 10.7270/Q23T9M14
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50479537 (CHEMBL504747) Show SMILES Cc1ccc(C)c(OCN2Cc3ccccc3C2C=O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<5.00E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of CYP3A4				J Med Chem 52: 1247-50 (2009) Article DOI: 10.1021/jm801278g BindingDB Entry DOI: 10.7270/Q23T9M14
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 3 (Homo sapiens (Human))	BDBM396097 (US10308663, JMS-631-053) Show SMILES N=C1c2sc(cc2C(=O)NC1=O)-c1ccccc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....				Bioorg Med Chem Lett 17: 4664-9 (2007) BindingDB Entry DOI: 10.7270/Q20867N2
Boehringer Ingelheim Pharmaceuticals Inc.					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336960 (3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...) Show SMILES Oc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28.3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336960 (3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...) Show SMILES Oc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28.3	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 3 (Homo sapiens (Human))	BDBM50535759 (CHEMBL4471843) Show SMILES O=C1NC(=O)C(=O)c2sc(cc12)-c1ccccc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incub...				Bioorg Med Chem Lett 29: 2008-2015 (2019) Article DOI: 10.1016/j.bmcl.2019.06.048 BindingDB Entry DOI: 10.7270/Q2VH5SBF
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 3 (Homo sapiens (Human))	BDBM396097 (US10308663, JMS-631-053) Show SMILES N=C1c2sc(cc2C(=O)NC1=O)-c1ccccc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incub...				Bioorg Med Chem Lett 29: 2008-2015 (2019) Article DOI: 10.1016/j.bmcl.2019.06.048 BindingDB Entry DOI: 10.7270/Q2VH5SBF
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Polycystin-2 (Homo sapiens (Human))	BDBM50336958 (2-Methoxy-7H,8H,9H-1,4-thiazepino[7',6'-5,4]thioph...) Show SMILES COc1ncc2sc3c(SCCNC3=O)c2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD2 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1 (Homo sapiens (Human))	BDBM396097 (US10308663, JMS-631-053) Show SMILES N=C1c2sc(cc2C(=O)NC1=O)-c1ccccc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of PTP4A1 (unknown origin) expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incubated for 30 mi...				Bioorg Med Chem Lett 29: 2008-2015 (2019) Article DOI: 10.1016/j.bmcl.2019.06.048 BindingDB Entry DOI: 10.7270/Q2VH5SBF
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 2 (Homo sapiens (Human))	BDBM396097 (US10308663, JMS-631-053) Show SMILES N=C1c2sc(cc2C(=O)NC1=O)-c1ccccc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of PTP4A2 (unknown origin) expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incubated for 30 mi...				Bioorg Med Chem Lett 29: 2008-2015 (2019) Article DOI: 10.1016/j.bmcl.2019.06.048 BindingDB Entry DOI: 10.7270/Q2VH5SBF
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D3 (Homo sapiens (Human))	BDBM50336960 (3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...) Show SMILES Oc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53.2	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D2 (Homo sapiens (Human))	BDBM50336960 (3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...) Show SMILES Oc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58.7	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D3 (Homo sapiens (Human))	BDBM50336962 (2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...) Show SMILES Oc1ccc2sc3c(SCCCNC3=O)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58.8	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336961 (3,4-Dihydro-9-azido-[1]benzothieno[2,3-f]-1,4-thia...) Show SMILES [N-]=[N+]=Nc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	74.9	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Homo sapiens (Human))	BDBM50267086 (Adociaquinone B \| CHEMBL476648) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Polytechnic Institute and State University Curated by ChEMBL					Assay Description Inhibition of histidine-tagged full length human Cdc25B expressed in Escherichia coli				Bioorg Med Chem 17: 2276-81 (2009) Article DOI: 10.1016/j.bmc.2008.10.090 BindingDB Entry DOI: 10.7270/Q21J99MN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) Show SMILES COc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	82.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) Show SMILES COc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	82.5	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 3 (Homo sapiens (Human))	BDBM396097 (US10308663, JMS-631-053) Show SMILES N=C1c2sc(cc2C(=O)NC1=O)-c1ccccc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human PTP4A3				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128167 BindingDB Entry DOI: 10.7270/Q23X8BDD
TBA					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D3 (Homo sapiens (Human))	BDBM81614 (kb-NB165-31) Show SMILES Oc1ccc2sc3c(SCCNC3=O)c2c1I Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	91.1	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D3 (Homo sapiens (Human))	BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) Show SMILES COc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	98.5	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D2 (Homo sapiens (Human))	BDBM50336962 (2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...) Show SMILES Oc1ccc2sc3c(SCCCNC3=O)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	101	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 3 (Homo sapiens (Human))	BDBM50571230 (CHEMBL4862721) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human PTP4A3				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128167 BindingDB Entry DOI: 10.7270/Q23X8BDD
TBA					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Homo sapiens (Human))	BDBM50267086 (Adociaquinone B \| CHEMBL476648) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Polytechnic Institute and State University Curated by ChEMBL					Assay Description Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coli				Bioorg Med Chem 17: 2276-81 (2009) Article DOI: 10.1016/j.bmc.2008.10.090 BindingDB Entry DOI: 10.7270/Q21J99MN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336962 (2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...) Show SMILES Oc1ccc2sc3c(SCCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	111	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336962 (2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...) Show SMILES Oc1ccc2sc3c(SCCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	111	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM81614 (kb-NB165-31) Show SMILES Oc1ccc2sc3c(SCCNC3=O)c2c1I Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336958 (2-Methoxy-7H,8H,9H-1,4-thiazepino[7',6'-5,4]thioph...) Show SMILES COc1ncc2sc3c(SCCNC3=O)c2n1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336959 (3,4,5,10-Tetrahydro-7-hydroxy-azepino[3,4-b]indol-...) Show SMILES Oc1ccc2[nH]c3c(CCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 3 (Homo sapiens (Human))	BDBM50059084 (CHEMBL3393171 \| US10308663, Thienopyridone (5)) Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as increase in polarization using TAMRAThr-Ala-Asp-Ile-Tyr...				Bioorg Med Chem Lett 29: 2008-2015 (2019) Article DOI: 10.1016/j.bmcl.2019.06.048 BindingDB Entry DOI: 10.7270/Q2VH5SBF
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 3 (Homo sapiens (Human))	BDBM50059084 (CHEMBL3393171 \| US10308663, Thienopyridone (5)) Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	132	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....				Bioorg Med Chem Lett 17: 4664-9 (2007) BindingDB Entry DOI: 10.7270/Q20867N2
Boehringer Ingelheim Pharmaceuticals Inc.					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D2 (Homo sapiens (Human))	BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) Show SMILES COc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	142	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D2 (Homo sapiens (Human))	BDBM81614 (kb-NB165-31) Show SMILES Oc1ccc2sc3c(SCCNC3=O)c2c1I Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	163	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1 (Homo sapiens (Human))	BDBM50059084 (CHEMBL3393171 \| US10308663, Thienopyridone (5)) Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of recombinant human His-6-tagged PTP4A1 expressed in Escherichia coli assessed as increase in polarization using TAMRAThr-Ala-Asp-Ile-Tyr...				Bioorg Med Chem Lett 29: 2008-2015 (2019) Article DOI: 10.1016/j.bmcl.2019.06.048 BindingDB Entry DOI: 10.7270/Q2VH5SBF
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM32334 (7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...) Show SMILES Oc1ccc2oc3c(CCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	182	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description The radiometric kinase assay using PKD kinase.				J Biol Chem 283: 33516-26 (2008) Article DOI: 10.1074/jbc.M805358200 BindingDB Entry DOI: 10.7270/Q20863WJ
University of Pittsburgh					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM32334 (7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...) Show SMILES Oc1ccc2oc3c(CCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	182	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM32334 (7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...) Show SMILES Oc1ccc2oc3c(CCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	182	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336963 (2,3,4,5-Tetrahydro-10-methoxybenzo[b]thieno[2,3-f]...) Show SMILES COc1ccc2sc3c(SCCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	193	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.				BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D
University of Pittsburgh					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336963 (2,3,4,5-Tetrahydro-10-methoxybenzo[b]thieno[2,3-f]...) Show SMILES COc1ccc2sc3c(SCCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	193	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein tyrosine phosphatase type IVA 3 (Homo sapiens (Human))	BDBM50571225 (CHEMBL4862502) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	206	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human PTP4A3				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128167 BindingDB Entry DOI: 10.7270/Q23X8BDD
TBA					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Homo sapiens (Human))	BDBM50106497 (6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human cell division cycle 25B				J Med Chem 44: 4042-9 (2001) BindingDB Entry DOI: 10.7270/Q2X34WR5
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D3 (Homo sapiens (Human))	BDBM32334 (7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...) Show SMILES Oc1ccc2oc3c(CCCNC3=O)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	227	n/a	n/a	n/a	n/a	7.5	30
University of Pittsburgh					Assay Description The radiometric kinase assay using PKD kinase.				J Biol Chem 283: 33516-26 (2008) Article DOI: 10.1074/jbc.M805358200 BindingDB Entry DOI: 10.7270/Q20863WJ
University of Pittsburgh					More data for this Ligand-Target Pair

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