| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 30 |
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| Ligand | BDBM490026 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2020815 (CHEMBL4674628) |
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| IC50 | 60±n/a nM |
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| Citation |  Kluge, AF; Lagu, BR; Maiti, P; Jaleel, M; Webb, M; Malhotra, J; Mallat, A; Srinivas, PA; Thompson, JE Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett28:2655-2659 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 30 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 30 |
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| Synonyms: | Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30 |
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| Type: | Protein |
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| Mol. Mass.: | 58522.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q70CQ3 |
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| Residue: | 517 |
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| Sequence: | MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERK
KRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTL
LHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQ
PRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQ
SPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEK
VEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLG
HKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMP
FPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDT
VRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
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| BDBM490026 |
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| n/a |
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| Name | BDBM490026 |
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| Synonyms: | (S)-N-(1-((4-(N-(tert- butyl)sulfamoyl)phenyl)amino)-1- oxo-3-phenylpropan-2- yl)cyclohexanecarboxamide | US10968172, ID # 10b |
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| Type | Small organic molecule |
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| Emp. Form. | C26H35N3O4S |
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| Mol. Mass. | 485.639 |
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| SMILES | CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2CCCCC2)cc1 |r| |
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| Structure | 
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