| Reaction Details |
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 | Report a problem with these data |
| Target | Hematopoietic prostaglandin D synthase |
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| Ligand | BDBM50463722 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2026087 (CHEMBL4679900) |
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| IC50 | 83±n/a nM |
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| Citation |  Yokoo, H; Shibata, N; Naganuma, M; Murakami, Y; Fujii, K; Ito, T; Aritake, K; Naito, M; Demizu, Y Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer. ACS Med Chem Lett12:236-241 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hematopoietic prostaglandin D synthase |
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| Name: | Hematopoietic prostaglandin D synthase |
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| Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 23341.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
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| Residue: | 199 |
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| Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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| BDBM50463722 |
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| n/a |
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| Name | BDBM50463722 |
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| Synonyms: | CHEMBL4238186 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29N5O4 |
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| Mol. Mass. | 487.5503 |
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| SMILES | O=C(Nc1ccc(cc1)N1CCC(CC1)C(=O)N1CCOCC1)c1cnc(Oc2ccccc2)nc1 |
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| Structure | 
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