| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-1 |
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| Ligand | BDBM50550642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2027957 (CHEMBL4682115) |
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| IC50 | 1600±n/a nM |
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| Citation |  Xie, SC; Gillett, DL; Spillman, NJ; Tsu, C; Luth, MR; Ottilie, S; Duffy, S; Gould, AE; Hales, P; Seager, BA; Charron, CL; Bruzzese, F; Yang, X; Zhao, X; Huang, SC; Hutton, CA; Burrows, JN; Winzeler, EA; Avery, VM; Dick, LR; Tilley, L Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome. J Med Chem61:10053-10066 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-1 |
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| Name: | Proteasome subunit beta type-1 |
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| Synonyms: | PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 26493.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1366691 |
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| Residue: | 241 |
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| Sequence: | MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEG
FSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAML
STILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQ
VGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRK
D
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| BDBM50550642 |
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| n/a |
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| Name | BDBM50550642 |
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| Synonyms: | CHEMBL4787081 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H45BN4O7S |
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| Mol. Mass. | 616.577 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)NCC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)B(O)O |r| |
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| Structure | 
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