BindingDB PrimarySearch

Found 65 hits with Last Name = 'hutton' and Initial = 'ca'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50550643 (CHEMBL4749207) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human 20S constitutive proteasome beta 5 subunit assessed as equilibrium constant using fluorogenic peptide Ac-WLA-AMC as substra...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Homo sapiens (Human))	BDBM50550643 (CHEMBL4749207) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	487	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human 20S constitutive proteasome beta 2 subunit assessed as equilibrium constant using fluorogenic peptide Ac-WLR-AMC as substra...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
4-hydroxy-tetrahydrodipicolinate synthase (Escherichia coli (strain K12))	BDBM19472 (2-oxoacetic acid \| Glyoxylate \| Oxoethanoic acid \|...) Show SMILES OC(=O)C=O Show InChI InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of Escherichia coli DHDPS				Bioorg Med Chem 16: 9975-83 (2008) Article DOI: 10.1016/j.bmc.2008.10.026 BindingDB Entry DOI: 10.7270/Q2FN1748
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-tetrahydrodipicolinate synthase (Bacillus subtilis)	BDBM50273973 (2,6-dioxoheptanedioic acid \| CHEMBL451265) Show SMILES OC(=O)C(=O)CCCC(=O)C(O)=O Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.60E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of Bacillus subtilis DHDPS				Bioorg Med Chem 16: 9975-83 (2008) Article DOI: 10.1016/j.bmc.2008.10.026 BindingDB Entry DOI: 10.7270/Q2FN1748
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-tetrahydrodipicolinate synthase (Escherichia coli (strain K12))	BDBM50160721 (2-Oxo-heptanedioic acid \| 2-oxoheptanedioic acid \|...) Show SMILES OC(=O)CCCCC(=O)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.70E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Binding affinity for Escherichia coli dihydrodipicolinate synthase				Bioorg Med Chem Lett 15: 995-8 (2005) Article DOI: 10.1016/j.bmcl.2004.12.043 BindingDB Entry DOI: 10.7270/Q26M36BS
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (Homo sapiens (Human))	BDBM50229870 (4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid \| ...) Show SMILES OC(=O)c1cc(O)cc(n1)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	1.70E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of dihydrodipicolinate synthase				Bioorg Med Chem Lett 18: 460-3 (2008) Article DOI: 10.1016/j.bmcl.2007.11.108 BindingDB Entry DOI: 10.7270/Q2QZ29QP
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (Homo sapiens (Human))	BDBM50160721 (2-Oxo-heptanedioic acid \| 2-oxoheptanedioic acid \|...) Show SMILES OC(=O)CCCCC(=O)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.70E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of dihydrodipicolinate synthase				Bioorg Med Chem Lett 18: 460-3 (2008) Article DOI: 10.1016/j.bmcl.2007.11.108 BindingDB Entry DOI: 10.7270/Q2QZ29QP
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-tetrahydrodipicolinate synthase (Escherichia coli (strain K12))	BDBM50160721 (2-Oxo-heptanedioic acid \| 2-oxoheptanedioic acid \|...) Show SMILES OC(=O)CCCCC(=O)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.70E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of Escherichia coli DHDPS				Bioorg Med Chem 16: 9975-83 (2008) Article DOI: 10.1016/j.bmc.2008.10.026 BindingDB Entry DOI: 10.7270/Q2FN1748
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-tetrahydrodipicolinate synthase (Escherichia coli (strain K12))	BDBM50273974 (3-fluoro-2-oxopropanoate) Show SMILES [O-]C(=O)C(=O)CF Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Patents	Article PubMed	2.20E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of Escherichia coli DHDPS				Bioorg Med Chem 16: 9975-83 (2008) Article DOI: 10.1016/j.bmc.2008.10.026 BindingDB Entry DOI: 10.7270/Q2FN1748
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (Homo sapiens (Human))	BDBM50411597 (CHEMBL403480) Show SMILES COC(=O)C(N=O)c1cccc(c1)C(N=O)C(=O)OC Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	3.30E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of dihydrodipicolinate synthase				Bioorg Med Chem Lett 18: 460-3 (2008) Article DOI: 10.1016/j.bmcl.2007.11.108 BindingDB Entry DOI: 10.7270/Q2QZ29QP
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-tetrahydrodipicolinate synthase (Escherichia coli (strain K12))	BDBM50273976 (2-oxopentanoate \| 2-oxovalerate \| alpha-ketovalera...) Show SMILES CCCC(=O)C([O-])=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	7.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of Escherichia coli DHDPS				Bioorg Med Chem 16: 9975-83 (2008) Article DOI: 10.1016/j.bmc.2008.10.026 BindingDB Entry DOI: 10.7270/Q2FN1748
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-tetrahydrodipicolinate synthase (Escherichia coli (strain K12))	BDBM50273975 (2-ketobutyrate \| 2-oxobutanate \| 2-oxobutanoate \| ...) Show SMILES CCC(=O)C([O-])=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	8.30E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of Escherichia coli DHDPS				Bioorg Med Chem 16: 9975-83 (2008) Article DOI: 10.1016/j.bmc.2008.10.026 BindingDB Entry DOI: 10.7270/Q2FN1748
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-tetrahydrodipicolinate synthase (Escherichia coli (strain K12))	BDBM50412477 (CHEMBL456159) Show SMILES OC(=O)\C=C\C(=O)\C=C\C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	1.63E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of Escherichia coli recombinant DHDPS overexpressed with DHDPR assessed as residual activity by modified coupled assay				Bioorg Med Chem 16: 9975-83 (2008) Article DOI: 10.1016/j.bmc.2008.10.026 BindingDB Entry DOI: 10.7270/Q2FN1748
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (Homo sapiens (Human))	BDBM50411596 (CHEMBL253062) Show SMILES OC(=O)C(=O)c1cccc(c1)C(=O)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	2.96E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of dihydrodipicolinate synthase				Bioorg Med Chem Lett 18: 460-3 (2008) Article DOI: 10.1016/j.bmcl.2007.11.108 BindingDB Entry DOI: 10.7270/Q2QZ29QP
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-tetrahydrodipicolinate synthase (Escherichia coli (strain K12))	BDBM50412479 (CHEMBL456197) Show SMILES CCOC(=O)\C=C\C(=O)\C=C\C(=O)OCC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	4.95E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of Escherichia coli recombinant DHDPS overexpressed with DHDPR assessed as residual activity by modified coupled assay				Bioorg Med Chem 16: 9975-83 (2008) Article DOI: 10.1016/j.bmc.2008.10.026 BindingDB Entry DOI: 10.7270/Q2FN1748
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-tetrahydrodipicolinate synthase (Escherichia coli (strain K12))	BDBM50412478 (CHEMBL178492) Show SMILES CCOC(=O)CCC(=O)C=CC(=O)OCC \|w:9.8\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.09E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of Escherichia coli recombinant DHDPS overexpressed with DHDPR assessed as residual activity by modified coupled assay				Bioorg Med Chem 16: 9975-83 (2008) Article DOI: 10.1016/j.bmc.2008.10.026 BindingDB Entry DOI: 10.7270/Q2FN1748
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (Homo sapiens (Human))	BDBM26116 (CHEMBL284104 \| Dipicolinate \| pyridine carboxylate...) Show SMILES OC(=O)c1cccc(n1)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.10E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of dihydrodipicolinate synthase				Bioorg Med Chem Lett 18: 460-3 (2008) Article DOI: 10.1016/j.bmcl.2007.11.108 BindingDB Entry DOI: 10.7270/Q2QZ29QP
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
4-hydroxy-tetrahydrodipicolinate synthase (Escherichia coli (strain K12))	BDBM50412480 (CHEMBL458071) Show SMILES OC(=O)CCC(=O)C=CC(O)=O \|w:7.6\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	3.24E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Inhibition of Escherichia coli recombinant DHDPS overexpressed with DHDPR assessed as residual activity by modified coupled assay				Bioorg Med Chem 16: 9975-83 (2008) Article DOI: 10.1016/j.bmc.2008.10.026 BindingDB Entry DOI: 10.7270/Q2FN1748
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM50550643 (CHEMBL4749207) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of P...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50550643 (CHEMBL4749207) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presen...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM50069989 ((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of P...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM50550642 (CHEMBL4787081) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of P...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-9 (Homo sapiens (Human))	BDBM50550643 (CHEMBL4749207) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence of PA2...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-9 (Homo sapiens (Human))	BDBM50069989 ((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence of PA2...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50069989 ((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presen...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Proteasome subunit beta type-9 (Homo sapiens (Human))	BDBM50550640 (CHEMBL4749043) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence of PA2...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50550642 (CHEMBL4787081) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presen...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-9 (Homo sapiens (Human))	BDBM50550641 (CHEMBL4781914) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence of PA2...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM50550640 (CHEMBL4749043) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of P...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-9 (Homo sapiens (Human))	BDBM50550642 (CHEMBL4787081) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence of PA2...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Homo sapiens (Human))	BDBM50550643 (CHEMBL4749207) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM50550641 (CHEMBL4781914) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of P...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Homo sapiens (Human))	BDBM50069989 ((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50550641 (CHEMBL4781914) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presen...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-10 (Homo sapiens (Human))	BDBM50550642 (CHEMBL4787081) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of PA28al...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50550640 (CHEMBL4749043) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presen...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-10 (Homo sapiens (Human))	BDBM50550643 (CHEMBL4749207) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of PA28al...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Homo sapiens (Human))	BDBM50550641 (CHEMBL4781914) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Homo sapiens (Human))	BDBM50550642 (CHEMBL4787081) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-10 (Homo sapiens (Human))	BDBM50069989 ((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of PA28al...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Homo sapiens (Human))	BDBM50550643 (CHEMBL4749207) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Homo sapiens (Human))	BDBM50069989 ((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Proteasome subunit beta type-1 (Homo sapiens (Human))	BDBM50550642 (CHEMBL4787081) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Homo sapiens (Human))	BDBM50550640 (CHEMBL4749043) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Homo sapiens (Human))	BDBM50550640 (CHEMBL4749043) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Homo sapiens (Human))	BDBM50550641 (CHEMBL4781914) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-10 (Homo sapiens (Human))	BDBM50550641 (CHEMBL4781914) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of PA28al...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Proteasome subunit beta type-10 (Homo sapiens (Human))	BDBM50550640 (CHEMBL4749043) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S immunoproteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of PA28al...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
TBA					More data for this Ligand-Target Pair
Mycocyclosin synthase (Mycobacterium tuberculosis)	BDBM50505738 (CHEMBL4565125) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Binding affinity to Mycobacterium tuberculosis His6-tagged CYP121 by UV-visible scanning spectrophotometric analysis				J Med Chem 62: 9792-9805 (2019) Article DOI: 10.1021/acs.jmedchem.9b01199 BindingDB Entry DOI: 10.7270/Q2BK1GPQ
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mycocyclosin synthase (Mycobacterium tuberculosis)	BDBM50505724 (CHEMBL4556539) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	2.94E+4	n/a	n/a	n/a	n/a	n/a
University of Melbourne Curated by ChEMBL					Assay Description Binding affinity to Mycobacterium tuberculosis CYP121 expressed in Escherichia coli HMS174 (DE3) by UV-visible scanning spectrophotometric analysis				J Med Chem 62: 9792-9805 (2019) Article DOI: 10.1021/acs.jmedchem.9b01199 BindingDB Entry DOI: 10.7270/Q2BK1GPQ
University of Melbourne Curated by ChEMBL					More data for this Ligand-Target Pair

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