| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-10 |
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| Ligand | BDBM50550640 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2027961 (CHEMBL4682119) |
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| IC50 | >10000±n/a nM |
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| Citation |  Xie, SC; Gillett, DL; Spillman, NJ; Tsu, C; Luth, MR; Ottilie, S; Duffy, S; Gould, AE; Hales, P; Seager, BA; Charron, CL; Bruzzese, F; Yang, X; Zhao, X; Huang, SC; Hutton, CA; Burrows, JN; Winzeler, EA; Avery, VM; Dick, LR; Tilley, L Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome. J Med Chem61:10053-10066 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-10 |
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| Name: | Proteasome subunit beta type-10 |
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| Synonyms: | LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28940.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_106197 |
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| Residue: | 273 |
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| Sequence: | MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRAT
NDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTR
ILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDR
FQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGR
YHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
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| BDBM50550640 |
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| n/a |
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| Name | BDBM50550640 |
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| Synonyms: | CHEMBL4749043 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H26BN3O5 |
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| Mol. Mass. | 375.227 |
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| SMILES | C[C@H](NC(=O)[C@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1ccccc1)B(O)O |r| |
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| Structure | 
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