| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM50214744 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2032523 (CHEMBL4686681) |
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| IC50 | >100000±n/a nM |
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| Citation |  Sang, Z; Wang, K; Bai, P; Wu, A; Shi, J; Liu, W; Zhu, G; Wang, Y; Lan, Y; Chen, Z; Zhao, Y; Qiao, Z; Wang, C; Tan, Z Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease. Eur J Med Chem194:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
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| Type: | Enzyme |
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| Mol. Mass.: | 67792.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22303 |
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| Residue: | 614 |
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| Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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| BDBM50214744 |
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| n/a |
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| Name | BDBM50214744 |
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| Synonyms: | (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid | (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid (10) | CHEMBL32749 | Ferulic acid (M5) | ferulic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C10H10O4 |
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| Mol. Mass. | 194.184 |
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| SMILES | COc1cc(\C=C\C(O)=O)ccc1O |
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| Structure | 
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