Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50114235 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_124642 |
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IC50 | 35±n/a nM |
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Citation | Dumas, J; Hatoum-Mokdad, H; Sibley, RN; Smith, RA; Scott, WJ; Khire, U; Lee, W; Wood, J; Wolanin, D; Cooley, J; Bankston, D; Redman, AM; Schoenleber, R; Caringal, Y; Gunn, D; Romero, R; Osterhout, M; Paulsen, H; Housley, TJ; Wilhelm, SM; Pirro, J; Chien, DS; Ranges, GE; Shrikhande, A; Muzsi, A; Bortolon, E; Wakefield, J; Gianpaolo Ostravage, C; Bhargava, A; Chau, T Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor. Bioorg Med Chem Lett12:1559-62 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50114235 |
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n/a |
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Name | BDBM50114235 |
Synonyms: | 1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-3-[4-(4-hydroxy-phenylsulfanyl)-phenyl]-urea | CHEMBL290971 |
Type | Small organic molecule |
Emp. Form. | C21H24N4O2S |
Mol. Mass. | 396.506 |
SMILES | Cn1nc(cc1NC(=O)Nc1ccc(Sc2ccc(O)cc2)cc1)C(C)(C)C |
Structure |
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