| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM50554896 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2050950 (CHEMBL4705649) |
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| Ki | 780±n/a nM |
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| Citation |  Wang, Z; Song, T; Guo, Z; Cao, K; Chen, C; Feng, Y; Wang, H; Yin, F; Zhou, S; Dai, J; Zhang, Z Targeting the Allosteric Pathway That Interconnects the Core-Functional Scaffold and the Distal Phosphorylation Sites for Specific Dephosphorylation of Bcl-2. J Med Chem63:13733-13744 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM50554896 |
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| n/a |
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| Name | BDBM50554896 |
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| Synonyms: | CHEMBL4791005 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H17BrN2O3S |
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| Mol. Mass. | 541.415 |
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| SMILES | OC(=O)c1ccc(CNC2=C(C#N)C(=O)c3cccc4c(Sc5ccc(Br)cc5)ccc2c34)cc1 |c:9| |
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| Structure | 
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