| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 4 |
|---|
| Ligand | BDBM50554961 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2051062 (CHEMBL4705761) |
|---|
| IC50 | 316±n/a nM |
|---|
| Citation |  Patterson, JR; Terrell, LR; Donatelli, CA; Holt, DA; Jolivette, LJ; Rivero, RA; Roethke, TJ; Shu, A; Stoy, P; Ye, G; Youngman, M; Lawhorn, BG Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions. J Med Chem63:14867-14884 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential cation channel subfamily V member 4 |
|---|
| Name: | Transient receptor potential cation channel subfamily V member 4 |
|---|
| Synonyms: | TRPV4 | TRPV4_HUMAN | Transient receptor potential cation channel subfamily V member 4 (TRPV4) | VRL2 | VROAC |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 98290.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9HBA0 |
|---|
| Residue: | 871 |
|---|
| Sequence: | MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP
GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN
KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL
TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT
ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI
VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS
NLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYD
LSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLC
AMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGV
NSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTG
TYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSC
RDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGE
TVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV
DEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDE
VVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL
|
|
|
|---|
| BDBM50554961 |
|---|
| n/a |
|---|
| Name | BDBM50554961 |
|---|
| Synonyms: | CHEMBL4754934 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H16ClF4N3O3S |
|---|
| Mol. Mass. | 465.85 |
|---|
| SMILES | N[C@@H](CCNS(=O)(=O)c1ccc(cc1Cl)C(F)(F)F)COc1ccc(C#N)c(F)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
