| Reaction Details |
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 | Report a problem with these data |
| Target | Folate receptor alpha |
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| Ligand | BDBM50557568 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2059597 (CHEMBL4714598) |
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| IC50 | 0.340000±n/a nM |
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| Citation |  Wallace-Povirk, A; Tong, N; Wong-Roushar, J; O'Connor, C; Zhou, X; Hou, Z; Bao, X; Garcia, GE; Li, J; Kim, S; Dann, CE; Matherly, LH; Gangjee, A Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors. Bioorg Med Chem37:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Folate receptor alpha |
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| Name: | Folate receptor alpha |
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| Synonyms: | Adult folate-binding protein | FBP | FOLR | FOLR1 | FOLR1_HUMAN | FR-alpha | Folate receptor 1 | Folate receptor, adult | KB cells FBP | Ovarian tumor-associated antigen MOv18 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 29827.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469596 |
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| Residue: | 257 |
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| Sequence: | MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPW
RKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQV
DQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHF
YFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWA
AWPFLLSLALMLLWLLS
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| BDBM50557568 |
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| n/a |
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| Name | BDBM50557568 |
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| Synonyms: | CHEMBL4790375 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N4O6S2 |
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| Mol. Mass. | 464.515 |
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| SMILES | Nc1nc2sc(CCCc3ccc(s3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1 |r| |
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| Structure | 
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