Reaction Details |
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Target | TGF-beta receptor type-2 |
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Ligand | BDBM50557739 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2059983 (CHEMBL4714984) |
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IC50 | 5.0±n/a nM |
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Citation | Miwa, S; Yokota, M; Ueyama, Y; Maeda, K; Ogoshi, Y; Seki, N; Ogawa, N; Nishihata, J; Nomura, A; Adachi, T; Kitao, Y; Nozawa, K; Ishikawa, T; Ukaji, Y; Shiozaki, M Discovery of Selective Transforming Growth Factor ? Type II Receptor Inhibitors as Antifibrosis Agents. ACS Med Chem Lett12:745-751 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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TGF-beta receptor type-2 |
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Name: | TGF-beta receptor type-2 |
Synonyms: | TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 64559.49 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_586859 |
Residue: | 567 |
Sequence: | MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFST
CDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPK
CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTE
LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK
HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG
TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE
HPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE
LEHLDRLSGRSCSEEKIPEDGSLNTTK
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BDBM50557739 |
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n/a |
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Name | BDBM50557739 |
Synonyms: | CHEMBL4798505 |
Type | Small organic molecule |
Emp. Form. | C14H14N4O2 |
Mol. Mass. | 270.2866 |
SMILES | COc1cc(ccn1)-c1cnn2cc(OC)c(C)nc12 |
Structure |
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