| Reaction Details |
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 | Report a problem with these data |
| Target | Activin receptor type-2A |
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| Ligand | BDBM50557741 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2059984 (CHEMBL4714985) |
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| IC50 | 1200±n/a nM |
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| Citation |  Miwa, S; Yokota, M; Ueyama, Y; Maeda, K; Ogoshi, Y; Seki, N; Ogawa, N; Nishihata, J; Nomura, A; Adachi, T; Kitao, Y; Nozawa, K; Ishikawa, T; Ukaji, Y; Shiozaki, M Discovery of Selective Transforming Growth Factor ? Type II Receptor Inhibitors as Antifibrosis Agents. ACS Med Chem Lett12:745-751 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Activin receptor type-2A |
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| Name: | Activin receptor type-2A |
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| Synonyms: | ACVR2 | ACVR2A | AVR2A_HUMAN | Activin receptor type-2A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57840.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_4501897 |
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| Residue: | 513 |
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| Sequence: | MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC
FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM
EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV
GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG
QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT
QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
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| BDBM50557741 |
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| n/a |
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| Name | BDBM50557741 |
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| Synonyms: | CHEMBL4750258 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12N4O2 |
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| Mol. Mass. | 256.26 |
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| SMILES | COc1cnc2c(cnn2c1)-c1ccnc(OC)c1 |
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| Structure | 
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