| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-8 |
|---|
| Ligand | BDBM50119257 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_46862 (CHEMBL659710) |
|---|
| IC50 | 200±n/a nM |
|---|
| Citation |  Linton, SD; Karanewsky, DS; Ternansky, RJ; Chen, N; Guo, X; Jahangiri, KG; Kalish, VJ; Meduna, SP; Robinson, ED; Ullman, BR; Wu, JC; Pham, B; Kodandapani, L; Smidt, R; Diaz, JL; Fritz, LC; von Krosigk, U; Roggo, S; Schmitz, A; Tomaselli, KJ Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization. Bioorg Med Chem Lett12:2973-5 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-8 |
|---|
| Name: | Caspase-8 |
|---|
| Synonyms: | Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | CASP8_HUMAN | Caspase | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated CED-3 homolog |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55373.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q14790 |
|---|
| Residue: | 479 |
|---|
| Sequence: | MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
|
|
|
|---|
| BDBM50119257 |
|---|
| n/a |
|---|
| Name | BDBM50119257 |
|---|
| Synonyms: | 3-{[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-propylcarbamoyl]-methoxy}-naphthalene-2-carboxylic acid | CHEMBL328155 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H24N2O8 |
|---|
| Mol. Mass. | 444.4346 |
|---|
| SMILES | CC(C)C(NC(=O)COc1cc2ccccc2cc1C(O)=O)C(=O)N[C@H]1CC(=O)OC1O |
|---|
| Structure | 
|
|---|
Search and Browse
