Reaction Details |
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Target | Caspase-7 |
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Ligand | BDBM50119260 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_46847 (CHEMBL657314) |
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IC50 | 11000±n/a nM |
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Citation | Linton, SD; Karanewsky, DS; Ternansky, RJ; Chen, N; Guo, X; Jahangiri, KG; Kalish, VJ; Meduna, SP; Robinson, ED; Ullman, BR; Wu, JC; Pham, B; Kodandapani, L; Smidt, R; Diaz, JL; Fritz, LC; von Krosigk, U; Roggo, S; Schmitz, A; Tomaselli, KJ Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization. Bioorg Med Chem Lett12:2973-5 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Caspase-7 |
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Name: | Caspase-7 |
Synonyms: | Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase |
Type: | Enzyme |
Mol. Mass.: | 34273.91 |
Organism: | Homo sapiens (Human) |
Description: | P55210 |
Residue: | 303 |
Sequence: | MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
FSQ
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BDBM50119260 |
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n/a |
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Name | BDBM50119260 |
Synonyms: | CHEMBL100559 | N-(2-Hydroxy-5-oxo-tetrahydro-furan-3-yl)-2-[2-(5-trifluoromethanesulfonylamino-naphthalen-1-yloxy)-acetylamino]-butyramide |
Type | Small organic molecule |
Emp. Form. | C22H24F3N3O8S |
Mol. Mass. | 547.501 |
SMILES | CC(C)C(NC(=O)COc1cccc2c(NS(=O)(=O)C(F)(F)F)cccc12)C(=O)N[C@H]1CC(=O)OC1O |
Structure |
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