Reaction Details | |||
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Target | Poly [ADP-ribose] polymerase tankyrase-1 | ||
Ligand | BDBM50557893 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2060530 (CHEMBL4715531) | ||
IC50 | 4.0±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Poly [ADP-ribose] polymerase tankyrase-1 | |||
Name: | Poly [ADP-ribose] polymerase tankyrase-1 | ||
Synonyms: | (ARTD5 or PARP5a) | PARP5A | PARPL | Poly [ADP-ribose] polymerase 5 (PARP5) | Poly [ADP-ribose] polymerase tankyrase-1 | TIN1 | TINF1 | TNKS | TNKS1 | TNKS1_HUMAN | Tankyrase 1 | Tankyrase 1/2 | Tankyrase-1 | Tankyrase-1 (TNKS-1) | Tankyrase-1 (TNKS1) | ||
Type: | Enzyme | ||
Mol. Mass.: | 142058.03 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O95271 | ||
Residue: | 1327 | ||
Sequence: |
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BDBM50557893 | |||
n/a | |||
Name | BDBM50557893 | ||
Synonyms: | CHEMBL4763370 | ||
Type | Small organic molecule | ||
Emp. Form. | C32H30F3N5O3 | ||
Mol. Mass. | 589.6075 | ||
SMILES | Cc1ccc(NC(=O)[C@H]2CC[C@H](Cn3c(=O)n(Cc4cccc(c4C#N)C(F)(F)F)c4cccc(C)c4c3=O)CC2)cn1 |r,wU:8.7,wD:11.11,(22.02,-20.64,;20.69,-19.87,;20.69,-18.32,;19.35,-17.56,;18.03,-18.33,;16.7,-17.56,;15.36,-18.32,;15.36,-19.86,;14.03,-17.55,;12.69,-18.32,;11.36,-17.56,;11.37,-16.01,;10.03,-15.25,;8.7,-16.02,;8.71,-17.57,;10.04,-18.34,;7.36,-18.35,;7.37,-19.89,;6.03,-20.67,;4.7,-19.9,;3.37,-20.67,;3.37,-22.21,;4.72,-22.98,;6.04,-22.2,;7.39,-22.96,;8.73,-23.72,;4.73,-24.52,;3.32,-25.22,;6.32,-24.65,;4.57,-25.96,;6.02,-17.59,;4.68,-18.35,;3.35,-17.58,;3.35,-16.04,;4.68,-15.27,;4.67,-13.73,;6.01,-16.03,;7.35,-15.24,;7.34,-13.7,;12.69,-15.24,;14.03,-16.01,;18.02,-19.87,;19.35,-20.64,)| | ||
Structure | ![]() |