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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
| Ligand | BDBM50558595 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2063959 (CHEMBL4719212) | ||
| IC50 | 40±n/a nM | ||
| Citation |  Balasubramanian, G; Narayanan, S; Andiappan, L; Sappanimuthu, T; Thirunavukkarasu, S; Sundaram, S; Natarajan, S; Sivaraman, N; Rajagopal, S; Nazumudeen, FAA; Saxena, S; Vishwakarma, SL; Narayanan, S; Sharma, GVR; Srinivasan, CV; Kilambi, N In vivo effective dibenzo[b,d]furan-1-yl-thiazoles as novel PDE-4 inhibitors. Bioorg Med Chem24:5702-5716 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
| Type: | Protein | ||
| Mol. Mass.: | 83318.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q07343 | ||
| Residue: | 736 | ||
| Sequence: |
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| BDBM50558595 | |||
| n/a | |||
| Name | BDBM50558595 | ||
| Synonyms: | CHEMBL4764245 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H23F2N3O5S | ||
| Mol. Mass. | 515.529 | ||
| SMILES | CC(=O)Nc1ccc2oc3c(OC(F)F)ccc(-c4nc(cs4)C(=O)NC4CCC(O)CC4)c3c2c1 |(67.92,-47.27,;67.3,-48.68,;68.21,-49.92,;65.78,-48.84,;65.16,-50.25,;66.07,-51.5,;65.45,-52.91,;63.91,-53.07,;63,-54.33,;61.53,-53.85,;60.2,-54.63,;60.2,-56.17,;58.87,-56.95,;58.88,-58.49,;57.54,-56.18,;58.86,-53.86,;58.86,-52.31,;60.2,-51.53,;60.19,-49.99,;61.43,-49.08,;60.95,-47.61,;59.4,-47.62,;58.93,-49.09,;61.85,-46.37,;61.22,-44.96,;63.38,-46.53,;64.28,-45.28,;63.65,-43.88,;64.55,-42.63,;66.08,-42.79,;66.99,-41.54,;66.71,-44.19,;65.81,-45.44,;61.53,-52.3,;63,-51.83,;63.63,-50.42,)| | ||
| Structure | 
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